TCI now offers hetero-bifunctional linkers with a variety of lengths since the length of linkers is an important factor in triggering Ubiquitination. Ubiquitination is a reaction in which ubiquitin proteins are added to a substrate protein by the action of ubiquitin ligases. The ubiquitinated protein is recognized by the proteasome and undergoes proteolysis.
Since its foundation in 1946, TCI’s philosophy has been to contribute to society through the manufacturing and supply of organic laboratory chemicals. We are proud, that today our company offers more than 30,000 quality reagents on a global basis. In recent years, our business has also expanded to the manufacturing of fine chemicals such as pharmaceutical and cosmetic raw materials, building blocks for synthesis of proteolysis targeting compounds and biconjugation.
In recent years, research in medicinal chemistry has increasingly investigated the use of the ubiquitin-proteasome system (UPS) to combat diseases. As a result, a variety of chimera compounds have been synthesized consisting of a tag that can bind to ubiquitin ligase, a linker and another ligand that can bind to disease related proteins. This enables us to bring the disease related protein in proximity to an activated UPS to eliminate the protein.
Measuring the activity of these compounds has shown that the length of the linker is an important factor in triggering ubiquination. TCI now offers hetero-bifunctional linkers with a variety of lengths. We are also open to inquiries regarding scale up and custom synthesis of linkers and ligands.
Tokyo Chemical Industry UK Ltd.
The Magdalen Centre
Robert Robinson Avenue
The Oxford Science Park,
Oxford OX4 4GA
Tel: 01865 784560
You can also contact our local sales representative Mr. Robbie Benning: Robbie.Benning@TCIchemicals.com