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Gain insights into membrane protein complexes using Molecular Dynamics simulatio...

Jul 19th 2023

Running Molecular Dynamics (MD) calculations with membrane proteins is one of the new features recently introduced within Flare. Not only do membrane proteins play a key role in a cell’s b...

Cresset June 2023 Newsletter

Jun 23rd 2023

We're pleased to announce the release of Torx 2.0 and the Flare Python Cookbook V3.0, alongside a variety of new science in the latest Cresset monthly newsletter.

Eating protein from lab-grown, plant and insect sources takes giant steps to wid...

Dec 7th 2022

Inside Green Innovation: Progress Report 2022, from leading intellectual property firm Appleyard Lees’, analyses patent filings across several key environmental issues facing the world, in...

Using molecular dynamics to produce an ensemble of protein conformations for mor...

Nov 3rd 2022

Ensemble Docking with Molecular Dynamics Proteins in Flare™

Identifying novel inhibitors against tuberculosis

Nov 3rd 2022

Using the active site to generate new designs for InhA reductase inhibitors

Leveraging protein DNA/RNA interactions in drug discovery

Oct 26th 2022

Relevant protein DNA/RNA processing complexes and their associated mechanisms provide interesting therapeutic targets to researchers, however, due to the complex and often delicate nature of...

Cresset October 2022 Newsletter

Oct 26th 2022

Read about our latest case studies, published papers, and upcoming events

Understanding the role of water in protein-ligand complexes and when to consider...

Jan 25th 2022

The role of water in drug discovery should never be ignored. Its importance in ligand binding is well accepted and has an essential role in protein-drug interactions. Its role has been well ...

Using EDTA as a Strategy to Reduce Protein Aggregation by Peak Proteins

Sep 27th 2021

Read a recent case study where a client requested the large-scale production of a protein that had previously been optimised for purification during feasibility studies.

The search for a better charge model

Aug 4th 2021

We present one of the most promising approaches to predicting protein-ligand interactions, compare it to Cresset’s existing methodology, and discuss what this means for future Cresset soft...

Building Blocks for Synthesis of Proteolysis Targeting Compounds

Jul 2nd 2021

TCI now offers hetero-bifunctional linkers with a variety of lengths since the length of linkers is an important factor in triggering Ubiquitination. Ubiquitination is a reaction in which ub...

Flare V5 released: Innovative science and synergy between ligand and structure-b...

Jun 30th 2021

We are delighted to announce that Flare™ V5 is now available. This release of Cresset’s comprehensive platform for drug design features new and enhanced science, integration of ligand- a...

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