SRG - Lead Scientist - Cell & Molecular Biology

Job Title:

Lead Scientist - Cell & Molecular Biology

Category:

Technical roles

Closing Date:

07/03/2025

Lead Scientist – Cell and Molecular Biology

Cheshire

The successful candidate will also apply their expertise in cell and molecular biology, together with understanding of novel therapeutic strategies and complex medicines to deliver impactful results characterising cellular target engagement and target validation studies and prosecuting therapeutic efficacy assays in vitro.

Main Duties:

• Lead a team of scientists with effective line management and matrix management of projects
• Establish and lead collaborations to develop solutions in drug discovery programmes.
• Lead the development of human cell assays for the evaluation of a wide range of small molecule, large molecule and novel therapeutics.
• Establish and validate experimental endpoints for medicine evaluation to industry standards.
• Design and deliver strategies to evaluate phenotypic responses of multiple cell populations and complex cell models and tissue samples including the assessment of therapeutic efficacy.
• Act as the in vitro technical expert for complex medicine evaluation
• Work in partnership with scientists in the fields of complex cell models, preclinical imaging, target engagement and target validation, in vitro and in vivo to deliver end-to-end workflows that can be applied to collaborative projects.

Ideal Candidate:

• PhD (or equivalent) in cell or molecular biology with relevant postdoctoral experience in therapeutic characterisation
• Experience of working in drug discovery, and developing in vitro assays ideally in an industry setting
• Extensive experience in molecular engineering of cells including lentiviral transduction, CRISPR techniques and molecular analysis technologies.
• Extensive experience in culture of mammalian cells including background of working with primary cells and iPSC derivatives and analysis of phenotypic responses.
• Experience in novel therapeutic approaches, for example with particular expertise in lipid nanoparticles, cancer vaccines, ADCs or other complex medicines.
• Proven expertise and good publication record in cell and molecular biology.
• Experience in line management and leadership of a team of scientists.
• Proven track record of leading and delivering projects in a collaborative environment with the ability to work on multiple projects simultaneously.

APPLY HERE